Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0331701
PubChem CID
Molecular Formula
C16H20N6O
Molecular Weight
312.377 g/mol
Synonyms/Alias
[CHEMBL1835057; SCHEMBL14975828; BDBM50419263]
InChI Key
ODRSUVBAJITCIK-GFCCVEGCSA-N
InChI
InChI=1S/C16H20N6O/c1-10-3-2-4-11(7-10)20-15-13(14(17)23)9-19-16(22-15)21-12-5-6-18-8-12/h2-4,7,9,12...
IUPAC Name
4-(3-methylanilino)-2-[[(3R)-pyrrolidin-3-yl]amino]pyrimidine-5-carboxamide
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

23 25 0 0 0 0 0 0 0 0999 V2000
1.9075 -5.4963 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.6672 -4.0156 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2648 -3...

Experimental Data

Activity Data

Target Ion Channel
Voltage-gated inwardly rectifying potassium channel KCNH2
Uniprot Accession Number
Function
Inhibitor
Species
Homo sapiens (Human)
IC50
IC50: 501 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
Not mention
Test Method
Fluorometric Imaging Plate Reader (FLIPR) Membrane Potential Assay
Test Species
Not specified

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
23
Rotatable Bonds
5
logP
1.4013
Complexity
89.909
TPSA (Ų)
104.96
H-Bond Donors
4
H-Bond Acceptors
6
Ring Count
3
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